Literature summary for 1.14.15.6 extracted from

Headlam, M.J.; Tuckey, R.C.
The effect of glycerol on cytochrome P450scc (CYP11A1) spin state, activity, and hydration (2002), Arch. Biochem. Biophys., 407, 95-102.

Search for more literature for 1.14.15.6

Inhibitors

Inhibitors	Comment	Organism	Structure
glycerol	substrate cholesterol, 50% inhibition at 25% glycerol, substrate 22(R)-hydroxycholesterol, 50% inhibition at 44% glycerol, substrate 20alpha-hydroxycholesterol, 50% inhibition at 48% glycerol, substrate 20alpha, 22(R)-dihydroxycholesterol, 50% inhibition at 51% glycerol	Bos taurus

Organic Solvent Stability

Organic Solvent	Comment	Organism
Glycerol	induces sigmoidal low-spin response of otherwise high-spin spectrum, weakens adrenodoxin binding, inhibitory effect being substrate dependent	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	enzyme incorporated into phosphatidylcholine vesicles	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adrenal gland	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
20alpha, 22(R)-dihydroxycholesterol + reduced adrenodoxin + O2	-	Bos taurus	? + oxidized adrenodoxin + H2O	-	?
20alpha-hydroxycholesterol + reduced adrenodoxin + O2	-	Bos taurus	pregnenolone + 4-methylpentanal + oxidized adrenodoxin + H2O	-	?
22(R)-hydroxycholesterol + reduced adrenodoxin + O2	-	Bos taurus	? + oxidized adrenodoxin + H2O	-	?
cholesterol + reduced adrenodoxin + O2	-	Bos taurus	? + oxidized adrenodoxin + H2O	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)