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Literature summary for 1.14.15.6 extracted from

  • Lambeth, J.D.; Kriengsiri, S.
    Cytochrome P-450scc-adrenodoxin interactions. Ionic effects on binding, and regulation of cytochrome reduction by bound steroid substrates (1985), J. Biol. Chem., 260, 8810-8816.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane integral to membrane Bos taurus 5743
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information several cations and anions promote the dissociation of adrenodoxin-cytochrome P-450scc complex, decreasing order: K+, Cs+, Rb+, Na+, Li+ and SCN-, Br-, Cl-, respectively. The order for dissotiation of adrenodoxin-adrenodoxin reductase complex: Rb+, Cs+, K+, Li+, Na+ Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + 6 reduced adrenodoxin + 3 O2 Bos taurus first step in biosynthesis of all steroid hormones pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + 6 reduced adrenodoxin + 3 O2 first step in biosynthesis of all steroid hormones Bos taurus pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
?
cholesterol + reduced adrenodoxin + O2 intermediates (22R)-22-hydroxycholesterol and (20R,22R)-20,22-dihydroxycholesterol from hydroxylation Bos taurus pregnenolone + 4-methylpentanal + oxidized adrenodoxin + H2O
-
?
cholesterol + reduced adrenodoxin + O2 regioselective and stereospecific transformation Bos taurus pregnenolone + 4-methylpentanal + oxidized adrenodoxin + H2O
-
?
cholesterol + reduced adrenodoxin + O2 intermediates 22R-hydroxycholesterol and 20alpha,22R-dihydroxycholesterol from hydroxylation Bos taurus pregnenolone + 4-methylpentanal + oxidized adrenodoxin + H2O
-
?
additional information electron shuttle between flavoprotein and cytochrome, biphasic reduction kinetics, rapid association of cytochrome and adrenodoxin, slower intracomplex electron transfer from iron-sulfur center of adrenodoxin to heme of cytochrome P-450scc Bos taurus ?
-
?
additional information suggested shuttle mechanism in which adrenodoxin transfers electrons between adrenodoxin reductase and cytochrome P-450. No ternary adrenodoxin-adrenodoxin reductase-P-450 complex Bos taurus ?
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?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Bos taurus
7
-
reduction of P-450scc-cholesterol complex by reduced adrenodoxin Bos taurus
7.2
-
maximal adrenodoxin-induced absorbance with 0.03 mM cholesterol Bos taurus

Cofactor

Cofactor Comment Organism Structure
adrenodoxin
-
Bos taurus
heme
-
Bos taurus
NADPH NADPH-linked adrenodoxin reductase Bos taurus