Cloned (Comment) | Organism |
---|---|
expression of wild-type CYP11B1 and of chimeric mutant CYP11B1/B2 in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a chimeric mutant from 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 genes analogously to the naturally occuring mutant resulting from an unequal crossover break point | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | estradiol has no effect on aldosterone production by wild-type CYP11B1 and chimeric mutant CYP11B1/B2 in HEK-293 cells | Homo sapiens | |
progesterone | progesterone acts as a competitive inhibitor for 11beta-hydroxylase and aldosterone synthase, inhibits aldosterone production by wild-type CYP11B1 and chimeric mutant CYP11B1/B2 in HEK-293 cells. The wild-type is more strongly inhibited than the chimera | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxylase | - |
Homo sapiens |
Aldosterone synthase | - |
Homo sapiens |
CYP11B1 | - |
Homo sapiens |
CYP11B2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
adrenodoxin | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | familial hyperaldosteronism type I is caused by the unequal recombination between the 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 genes, resulting in the generation of a CYP11B1/B2 chimeric gene and abnormal adrenal aldosterone production, which leads to severe hypertension and an elevated frequency of stroke at a young age | Homo sapiens |
additional information | molecular modelling of CYP11B1 and CYP11B1/B2 chimeric proteins and steroids docking, overview | Homo sapiens |
physiological function | progesterone might regulate the 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 enzymatic activities and contribute to the decay of aldosterone synthase activity in CYP11B1/B2 chimeric gene-positive patients. This regulatory mechanism of progesterone action might be involved in protecting pregnant women with FH-1 against hypertension | Homo sapiens |