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Literature summary for 1.14.15.18 extracted from

  • Ritter, C.S.; Haughey, B.H.; Armbrecht, H.J.; Brown, A.J.
    Distribution and regulation of the 25-hydroxyvitamin D3 1alpha-hydroxylase in human parathyroid glands (2012), J. Steroid Biochem. Mol. Biol., 130, 73-80.
    View publication on PubMed

Application

Application Comment Organism
medicine hyperplastic parathyroid glands from patients with chronic kidney failure normally display a heterogeneous cellularity. 25-hydroxyvitamin D3 1alpha-hydroxylase is expressed at much higher levels in oxyphil cells than in chief cells in these patients. The calcimimetic cinacalcet increases the expression of the enzyme in human parathyroid cultures. The enzyme in human parathyroid cultures is functionally active Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
parathyroid gland
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
1alphaOHase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens hyperplastic parathyroid glands from patients with chronic kidney failure normally display a heterogeneous cellularity. 25-hydroxyvitamin D3 1alpha-hydroxylase is expressed at much higher levels in oxyphil cells than in chief cells in these patients. The calcimimetic cinacalcet increases the expression of the enzyme in human parathyroid cultures up