Activating Compound | Comment | Organism | Structure |
---|---|---|---|
malate | supports 1alpha-hydroxylation as electron donor | Mammalia | |
succinate | supports 1alpha-hydroxylation as electron donor | Mammalia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antimycin A | - |
Mammalia | |
CN- | - |
Mammalia | |
CO | - |
Mammalia | |
cyanide | - |
Mammalia | |
dinitrophenol | - |
Mammalia | |
Glutethimide | - |
Mammalia | |
Metyrapone | - |
Mammalia | |
Natural inhibitors | vitamin D binding protein | Mammalia | |
rotenone | - |
Mammalia |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | almost any other Krebs cycle substrate supports 1-alpha-hydroxylation | Mammalia |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
ferredoxin, ferredoxin reductase and cytochrome P-450 | Mammalia |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O | 25-hydroxyvitamin D3 1alpha-hydroxylase is a cytochrome P-450-dependent mixed-function oxidase | Mammalia | |
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O | ferredoxin, ferredoxin reductase and cytochrome P-450 | Mammalia |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mammalia | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
calcidiol + NADPH + O2 | highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol | Mammalia | calcitriol + NADP+ + H2O | calcitriol is identical with 1,25-dihydroxycholecalciferol | ? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mammalia |