Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | the enzyme is absent from the liver and osteoclasts | Mus musculus | - |
kidney | the enzyme is absent from the liver and osteoclasts | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1alpha,23,25-trihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Mus musculus | 1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O | - |
? | |
1alpha,23,25-trihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Homo sapiens | 1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O | - |
? | |
1alpha,24R,25-trihydroxyvitamin D3 + NADPH + O2 | - |
Mus musculus | calcitroic acid + NADP+ + ? | - |
? | |
1alpha,24R,25-trihydroxyvitamin D3 + NADPH + O2 | - |
Homo sapiens | calcitroic acid + NADP+ + ? | - |
? | |
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Mus musculus | 1alpha,23,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Homo sapiens | 1alpha,23,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Mus musculus | 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Homo sapiens | 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D3 + NADPH + H+ + O2 | - |
Mus musculus | 24R,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D3 + NADPH + H+ + O2 | - |
Homo sapiens | 24R,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
calcidiol + NADPH + H+ + O2 | - |
Mus musculus | secalciferol + NADP+ + H2O | - |
? | |
calcidiol + NADPH + H+ + O2 | - |
Homo sapiens | secalciferol + NADP+ + H2O | - |
? | |
calcitriol + NADPH + H+ + O2 | - |
Mus musculus | calcitetrol + NADP+ + H2O | - |
? | |
calcitriol + NADPH + H+ + O2 | - |
Homo sapiens | calcitetrol + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
25-OH-D3-24-hydroxylase | - |
Mus musculus |
25-OH-D3-24-hydroxylase | - |
Homo sapiens |
CYP24A1 | - |
Mus musculus |
CYP24A1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | CYP24A1 is transcriptionally induced in vitamin D target cells by the action of 1alpha,25-dihydroxyvitamin D3 | up |
Homo sapiens | CYP24A1 is transcriptionally induced in vitamin D target cells by the action of 1alpha,25-dihydroxyvitamin D3 | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the Cyp24a1 knockout mouse is consistent with a catabolic role for CYP24A1, because it shows poor viability, 50% of homozygous mice die before weaning, showing hypercalcemia and signs of renal calcification. Isolated cultured keratinocytes from Cyp24a1-deficient mice fail to synthesize calcitroic acid | Mus musculus |
physiological function | CYP24A1 has a crucial role in vitamin D inactivation in vivo | Mus musculus |
physiological function | CYP24A1 has a crucial role in vitamin D inactivation in vivo | Homo sapiens |