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Literature summary for 1.14.14.9 extracted from
- Regulation of the 4-hydroxyphenylacetic acid meta-cleavage pathway in an Acinetobacter sp (1977), Biochem. Biophys. Res. Commun., 79, 663-670.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | 3B-3 mutant deficient in the metabolism of 4-hydroxyphenylacetic acid are created by exposure to N-methyl-N'-nitro-N-nitrosoguanidine | Acinetobacter sp. |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylacetate + NADH + O2 | Acinetobacter sp. | - |
3,4-dihydroxyphenylacetate + NAD+ + H2O | - |
? |  |
| 4-hydroxyphenylacetate + NADH + O2 | Acinetobacter sp. 3B-1 | - |
3,4-dihydroxyphenylacetate + NAD+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acinetobacter sp. | - |
wild-type strain 3B-1 and mutant 3B-3 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O | enzymes of 4-hydroxyphenylacetic acid meta-cleavage pathway are sythesized following at least two sequential inductive events | Acinetobacter sp. |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
no functional enzyme and activity detected for mutant, wild-type shows activity only if exposed to 4-hydroxyphenylacetate | Acinetobacter sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylacetate + NADH + O2 | - |
Acinetobacter sp. | 3,4-dihydroxyphenylacetate + NAD+ + H2O | - |
? | |
| 4-hydroxyphenylacetate + NADH + O2 | enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis | Acinetobacter sp. | 3,4-dihydroxyphenylacetate + NAD+ + H2O | - |
ir | |
| 4-hydroxyphenylacetate + NADH + O2 | - |
Acinetobacter sp. 3B-1 | 3,4-dihydroxyphenylacetate + NAD+ + H2O | - |
? | |
| 4-hydroxyphenylacetate + NADH + O2 | enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis | Acinetobacter sp. 3B-1 | 3,4-dihydroxyphenylacetate + NAD+ + H2O | - |
ir | |
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