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Literature summary for 1.14.14.37 extracted from

  • Clausen, M.; Kannangara, R.M.; Olsen, C.E.; Blomstedt, C.K.; Gleadow, R.M.; Jorgensen, K.; Bak, S.; Motawie, M.S.; Moller, B.L.
    The bifurcation of the cyanogenic glucoside and glucosinolate biosynthetic pathways (2015), Plant J., 84, 558-573.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Nicotiana tabacum Sorghum bicolor

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Sorghum bicolor 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E)-4-Hydroxyphenylacetaldehyde oxime Sorghum bicolor
-
(Z)-4-Hydroxyphenylacetaldehyde oxime
-
?
(E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH-hemoprotein reductase] + O2 Sorghum bicolor
-
(S)-4-hydroxymandelonitrile + [oxidized NADPH-hemoprotein reductase] + 2 H2O overall reaction ?
(Z)-4-hydroxyphenylacetaldehyde oxime Sorghum bicolor
-
4-hydroxyphenylacetonitrile + H2O
-
?
4-hydroxyphenylacetonitrile + [reduced NADPH-hemoprotein reductase] + O2 Sorghum bicolor
-
(S)-4-hydroxymandelonitrile + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Sorghum bicolor O48958
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E)-4-Hydroxyphenylacetaldehyde oxime
-
Sorghum bicolor (Z)-4-Hydroxyphenylacetaldehyde oxime
-
?
(E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH-hemoprotein reductase] + O2
-
Sorghum bicolor (S)-4-hydroxymandelonitrile + [oxidized NADPH-hemoprotein reductase] + 2 H2O overall reaction ?
(Z)-4-hydroxyphenylacetaldehyde oxime
-
Sorghum bicolor 4-hydroxyphenylacetonitrile + H2O
-
?
4-hydroxyphenylacetonitrile + [reduced NADPH-hemoprotein reductase] + O2
-
Sorghum bicolor (S)-4-hydroxymandelonitrile + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

General Information

General Information Comment Organism
physiological function the biosynthetic pathway for the cyanogenic glucoside dhurrin in Sorghum involves the sequential production of (E)- and (Z)-4-hydroxyphenylacetaldoxime. Monooxygenae CYP79A1 catalyzes conversion of tyrosine to (E)-4-hydroxyphenylacetaldoxime, whereas monooxygenase CYP71E1 catalyzes conversion of (E)-4-hydroxyphenylacetaldoxime into the corresponding geometrical Z-isomer as required for its dehydration into a nitrile, the next intermediate in cyanogenic glucoside synthesis Sorghum bicolor