Cloned (Comment) | Organism |
---|---|
from pCMV6 vector overexpressed in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5alpha-androstane-3alpha,17beta-diol | inhibition of the reaction with dehydroepiandrosterone | Homo sapiens | |
5alpha-androstane-3alpha,17beta-diol | inhibition of the reaction with dehydroepiandrosterone; significantly inhibits CYP7B1-mediated 7alpha-hydroxylation | Sus scrofa | |
additional information | testosterone, dehydroepiandrosterone-sulfate or 22-hydroxycholesterol have little or no effects on CYP7B1-mediated activities | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Sus scrofa | - |
- |
microsome | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | O75881 | - |
- |
Mus musculus | Q60991 | - |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
liver | - |
Sus scrofa | - |
liver | - |
Mus musculus | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Homo sapiens | 5alpha-androstane-3alpha,7alpha,17beta-triol + NADP+ + H2O | major product, plus some hydroxylation at position 6 | ? | |
5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Sus scrofa | 5alpha-androstane-3alpha,7alpha,17beta-triol + NADP+ + H2O | major product, plus some hydroxylation at position 6 | ? | |
5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Sus scrofa | ? + NADP+ + H2O | - |
? | |
5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Homo sapiens | ? + NADP+ + H2O | - |
? | |
5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Mus musculus | ? + NADP+ + H2O | - |
? | |
dehydroepiandrosterone + NADPH + H+ + o2 | - |
Mus musculus | 7alpha-hydroxy-dehydroepiandrosterone + NADP+ + H2O | - |
? | |
dehydroepiandrosterone + NADPH + H+ + O2 | - |
Homo sapiens | ? + NADP+ + H2O | - |
? | |
dehydroepiandrosterone + NADPH + H+ + O2 | - |
Sus scrofa | ? + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP7B1 | - |
Homo sapiens |
CYP7B1 | - |
Sus scrofa |
CYP7B1 | - |
Mus musculus |
Steroid hydroxylase | - |
Sus scrofa |
Steroid hydroxylase | - |
Homo sapiens |
Steroid hydroxylase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Sus scrofa | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | activity towards 5alpha-androstane-3alpha,17beta-diol is very low or undetectable in livers of Cyp7b1(-/-) knockout mice. CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens | Mus musculus |
physiological function | CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens | Sus scrofa |
physiological function | CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens | Homo sapiens |