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Literature summary for 1.14.14.29 extracted from

  • Pandak William, M.; Hylemon Phillip, B.; Ren, S.; Marques, D.; Gil, G.; Redford, K.; Mallonee, D.; Vlahcevic, Z.R.
    Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes (2002), Hepatology, 35, 1400-1408.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus both phorbol myristate acetate and cAMP decreases CYP7B1 activity by 60% and 34% respectively, in a time-dependent fashion. Changes in CYP7B1 messenger RNA levels correlate with changes in specific activities. CYP7B1 specific activity is highly regulated but does not seem to be rate limiting for bile acid synthesis ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information both phorbol myristate acetate and cAMP decreases CYP7B1 activity by 60% and 34% respectively, in a time-dependent fashion. Changes in CYP7B1 messenger RNA levels correlate with changes in specific activities. CYP7B1 specific activity is highly regulated but does not seem to be rate limiting for bile acid synthesis Rattus norvegicus ?
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