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Literature summary for 1.14.14.26 extracted from
- Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol (2000), J. Biol. Chem., 275, 16543-16549.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | Q9JKJ9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | sexually dimorphic expression pattern, higher expression in female than in male | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 | activity is largely restricted to 24-hydroxycholesterol | Homo sapiens | (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O | - |
? |  |
| (24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 | activity is largely restricted to 24-hydroxycholesterol | Mus musculus | (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 24-hydroxycholesterol 7alpha-monooxygenase | - |
Homo sapiens |
| 24-hydroxycholesterol 7alpha-monooxygenase | - |
Mus musculus |
| Cyp39a1 | - |
Homo sapiens |
| Cyp39a1 | - |
Mus musculus |
| CYP39A1 oxysterol 7alpha-hydroxylase | - |
Homo sapiens |
| CYP39A1 oxysterol 7alpha-hydroxylase | - |
Mus musculus |
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