Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.25 extracted from

  • Liao, W.L.; Heo, G.Y.; Dodder, N.G.; Reem, R.E.; Mast, N.; Huang, S.; Dipatre, P.L.; Turko, I.V.; Pikuleva, I.A.
    Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain (2011), J. Proteome Res., 10, 241-248.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.25

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli GC5 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Homo sapiens
-
 (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9Y6A2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview Homo sapiens
-
additional information quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview Homo sapiens
-
neuron
-
 Homo sapiens
-
retina
-
 Homo sapiens
-
retina quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP46A1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens