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Literature summary for 1.14.14.25 extracted from

  • Cartagena, C.M.; Burns, M.P.; Rebeck, G.W.
    24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury (2010), Brain Res., 1319, 1-12.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.25

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Homo sapiens
-
 (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain expression of Cyp46 in the brain is altered during normal development but is relatively stable in normal adult brain Homo sapiens
-
microglia
-
 Homo sapiens
-
neuroblastoma cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol 24S-hydroxylase
-
 Homo sapiens
CYP46
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Cyp46 is upregulated in traumatic brain injury, specifically in microglia up

General Information

General Information Comment Organism
metabolism cholesterol 24S-hydroxylase is a cholesterol metabolic enzyme with regulatory function in traumatic brain injury, overview Homo sapiens
additional information Cyp46 is upregulated in traumatic brain injury. Membrane damage during traumatic brain injury alters the brain homeostasis of cholesterol and other lipids. Reaction product 24S-hydroxycholesterol decreases mRNA levels of the cholesterol synthesis genes HMG CoA reductase, squalene synthase, and FPP synthase but does not alter levels of the mRNA of fatty acid synthesis genes acetyl CoA carboxylase or fatty acid synthase Homo sapiens
physiological function 24S-hydroxycholesterol and LXR agonist TO-901317 both increase SREBP-1 mRNA levels while 24S-hydroxycholesterol decreases SREBP-2 mRNA levels, real-time PCR quantification, overview Homo sapiens