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Literature summary for 1.14.14.25 extracted from

  • Solomon, A.; Leoni, V.; Kivipelto, M.; Besga, A.; Oksengard, A.R.; Julin, P.; Svensson, L.; Wahlund, L.O.; Andreasen, N.; Winblad, B.; Soininen, H.; Bjoerkhem, I.
    Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimers disease (2009), Neurosci. Lett., 462, 89-93.
    View publication on PubMed
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Application

Application Comment Organism
medicine abnormal expression of cholesterol 24S-hydroxylase in astrocytes in Alzheimer's disease, which may limit the usefulness of the plasma marker 24S-hydroxycholesterol in this specific disease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
glial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP46
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens