Cloned (Comment) | Organism |
---|---|
full ORF expression clone p46+ including the full cyp46A1 mouse open reading frame. Cyp46A1 overexpressed in 10 days in vitro hippocampal neurons | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
shRNA | knockdown | Mus musculus | |
siRNA | reduction of the cholesterol 24-hydroxylase, which results in lower levels of Trk phosphorylation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Mus musculus | - |
embryo | - |
Rattus norvegicus | - |
hippocampus | - |
Mus musculus | - |
hippocampus | - |
Rattus norvegicus | - |
neuron | - |
Mus musculus | - |
neuron | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
CYP46A1 | - |
Mus musculus |
CYP46A1 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | age-associated increase in TrkB activity correlates with a mild yet progressive loss of cholesterol, which, in turn, correlates with increased expression of the cholesterol catabolic enzyme cholesterol 24-hydroxylase. Increased expression of cholesterol-24-hydroxylase in the hippocampus of aged mice | up |
General Information | Comment | Organism |
---|---|---|
physiological function | cholesterol 24-hydroxylase regulates TrkB activity in mature hippocampal neurons | Mus musculus |
physiological function | cholesterol 24-hydroxylase regulates TrkB activity in mature hippocampal neurons | Rattus norvegicus |