Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
C57/B6-J mice | - |
Mus musculus C57B6-J | - |
C57/B6-J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | greater CYP46A1 levels in the brain than in the liver | Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | greater CYP46A1 levels in the brain than in the liver | Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CYP46A1 | - |
Mus musculus |
CYP46A1 | - |
Homo sapiens |
cytochrome P450 cholesterol 24-hydroxylase | - |
Mus musculus |
cytochrome P450 cholesterol 24-hydroxylase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | intraperitoneal injection of a high dose of valproate (700 mg/kg) results in a modest induction of the mRNA expression of CYP46A1 in the liver, and CYP46A1 in the brain. Intraperitoneal injection of trichostatin A to male mice results in dose dependent increases in the expression of brain and liver CYP46A1 | up |
Homo sapiens | marked time-dependent derepression of the expression of CYP46A1, in response to treatment with the potent histone deacetylase inhibitor trichostatin A. Treatment with 0.0005 mM trichostatin A for 48 h shows highly significant 150fold increase in CYP46A1 expression | up |