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Literature summary for 1.14.14.25 extracted from
- Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study (2009), Int. J. Geriatr. Psychiatry, 24, 921-926.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | genotyping of CYP46A1 gene polymorphisms (associated with the risk of Alzheimer's disease in Chinese) | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cholesterol 24-hydroxylase | - |
Homo sapiens |
| CYP46A1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | CYP46A1 gene may act to modulate the course of cognitive deterioration in late life. IVS2-150 polymorphism is associated with a higher risk of cognitive deterioration in Chinese older persons. IVS3-128 CC genotype is higher in improved or stable group, suggesting a protective role. Ppolymorphisms IVS1-192 and IVS4-122 do not show any significant association with cognitive function | Homo sapiens |
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