Cloned (Comment) | Organism |
---|---|
gene CYP46A1, expressionin CHO-K1 cells and HEK-293 cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | dendritic | Mus musculus | 5783 | - |
microsome | - |
Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | a cytochrome P450 enzyme | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | Mus musculus | the enzyme is required for learning and memory formation, mice deficient in CYP46A1 exhibit impaired learning and defective hippocampal long-term potentiation, overview | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
cerebellum | cerebellar interneurons and Purkinje cells | Mus musculus | - |
cerebral cortex | pyramidal neurons | Mus musculus | - |
dendritic cell | - |
Mus musculus | - |
hippocampus | pyramidal neurons | Mus musculus | - |
additional information | immunohistochemic analysis of enzyme distribution, overview | Mus musculus | - |
neuron | - |
Mus musculus | - |
Purkinje cell | in the cerebellum | Mus musculus | - |
retina | ganglion cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Mus musculus | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | the enzyme is required for learning and memory formation, mice deficient in CYP46A1 exhibit impaired learning and defective hippocampal long-term potentiation, overview | Mus musculus | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP46A1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | a cytochrome P450 enzyme | Mus musculus | |
NADPH | - |
Mus musculus |