Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | Rattus norvegicus | the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | Bos taurus | the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
calf | - |
Rattus norvegicus | - |
Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | immunohistochemic analysis of enzyme distribution | Rattus norvegicus | - |
additional information | immunohistochemic analysis of enzyme distribution | Bos taurus | - |
neuron | of the neural retina, specific expression of CYP46A1 | Rattus norvegicus | - |
neuron | of the neural retina, specific expression of CYP46A1 | Bos taurus | - |
retina | specific high expression of CYP46A1 in the neural retina, low expression in the retinal pigment epithelium, no expression in the ciliary body | Rattus norvegicus | - |
retina | specific high expression of CYP46A1 in the neural retina, low expression in the retinal pigment epithelium, no expression in the ciliary body | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Rattus norvegicus | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Bos taurus | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview | Rattus norvegicus | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview | Bos taurus | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Bos taurus |