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Literature summary for 1.14.14.25 extracted from

  • Luetjohann, D.
    Cholesterol metabolism in the brain: importance of 24S-hydroxylation (2006), Acta Neurol. Scand., 114 (Suppl. 185), 33-42.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and analysis Mus musculus
DNA sequence determination and analysis, located on chromosome14q32.1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of knockout mice, concentration and the pool of cholesterol in the CNS is unchanged compared with control animals, but synthesis is suppressed by about 25% in the CYP46a1-deficient mice, but not in those lacking 7a- or 27-hydroxylase activity, the concentrations of 24S-hydroxycholesterol in the brain and plasma decline to very low levels, the CNS in the mouse apparently responds appropriately to loss of this excretory pathway by suppressing endogenous synthesis by an amount exactly equal to the mass of cholesterol that would normally be excreted as 24S-hydroxycholesterol Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Mus musculus 5783
-
endoplasmic reticulum
-
Homo sapiens 5783
-
microsome of brain Sus scrofa
-
-
mitochondrion of liver Sus scrofa 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + NADPH + O2 Mus musculus the enzyme is important in cholesterol metabolism in the brain, cholesterol dynamics in the fetal and neonatal brain, overview (24S)-hydroxycholesterol + NADP+ + H2O the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview ?
cholesterol + NADPH + O2 Homo sapiens the enzyme is important in cholesterol metabolism in the brain, overview (24S)-hydroxycholesterol + NADP+ + H2O the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview ?
cholesterol + NADPH + O2 Sus scrofa the enzyme is important in cholesterol metabolism in the brain, overview (24S)-hydroxycholesterol + NADP+ + H2O the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain low activity Sus scrofa
-
brain cholesterol 24-hydroxylase is expressed predominantly in the brain Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Sus scrofa
-
neuron
-
Mus musculus
-
neuron
-
Homo sapiens
-
neuron
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + NADPH + O2
-
Mus musculus (24S)-hydroxycholesterol + NADP+ + H2O
-
?
cholesterol + NADPH + O2
-
Homo sapiens (24S)-hydroxycholesterol + NADP+ + H2O
-
?
cholesterol + NADPH + O2
-
Sus scrofa (24S)-hydroxycholesterol + NADP+ + H2O
-
?
cholesterol + NADPH + O2 the enzyme is important in cholesterol metabolism in the brain, cholesterol dynamics in the fetal and neonatal brain, overview Mus musculus (24S)-hydroxycholesterol + NADP+ + H2O the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview ?
cholesterol + NADPH + O2 the enzyme is important in cholesterol metabolism in the brain, overview Homo sapiens (24S)-hydroxycholesterol + NADP+ + H2O the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview ?
cholesterol + NADPH + O2 the enzyme is important in cholesterol metabolism in the brain, overview Sus scrofa (24S)-hydroxycholesterol + NADP+ + H2O the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview ?

Synonyms

Synonyms Comment Organism
CYP46A1
-
Mus musculus
CYP46A1
-
Homo sapiens
CYP46A1
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus
NADPH
-
Homo sapiens
NADPH
-
Sus scrofa