Cloned (Comment) | Organism |
---|---|
DNA sequence determination and analysis | Mus musculus |
DNA sequence determination and analysis, located on chromosome14q32.1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of knockout mice, concentration and the pool of cholesterol in the CNS is unchanged compared with control animals, but synthesis is suppressed by about 25% in the CYP46a1-deficient mice, but not in those lacking 7a- or 27-hydroxylase activity, the concentrations of 24S-hydroxycholesterol in the brain and plasma decline to very low levels, the CNS in the mouse apparently responds appropriately to loss of this excretory pathway by suppressing endogenous synthesis by an amount exactly equal to the mass of cholesterol that would normally be excreted as 24S-hydroxycholesterol | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
microsome | of brain | Sus scrofa | - |
- |
mitochondrion | of liver | Sus scrofa | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + NADPH + O2 | Mus musculus | the enzyme is important in cholesterol metabolism in the brain, cholesterol dynamics in the fetal and neonatal brain, overview | (24S)-hydroxycholesterol + NADP+ + H2O | the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview | ? | |
cholesterol + NADPH + O2 | Homo sapiens | the enzyme is important in cholesterol metabolism in the brain, overview | (24S)-hydroxycholesterol + NADP+ + H2O | the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview | ? | |
cholesterol + NADPH + O2 | Sus scrofa | the enzyme is important in cholesterol metabolism in the brain, overview | (24S)-hydroxycholesterol + NADP+ + H2O | the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | low activity | Sus scrofa | - |
brain | cholesterol 24-hydroxylase is expressed predominantly in the brain | Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Sus scrofa | - |
neuron | - |
Mus musculus | - |
neuron | - |
Homo sapiens | - |
neuron | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + NADPH + O2 | - |
Mus musculus | (24S)-hydroxycholesterol + NADP+ + H2O | - |
? | |
cholesterol + NADPH + O2 | - |
Homo sapiens | (24S)-hydroxycholesterol + NADP+ + H2O | - |
? | |
cholesterol + NADPH + O2 | - |
Sus scrofa | (24S)-hydroxycholesterol + NADP+ + H2O | - |
? | |
cholesterol + NADPH + O2 | the enzyme is important in cholesterol metabolism in the brain, cholesterol dynamics in the fetal and neonatal brain, overview | Mus musculus | (24S)-hydroxycholesterol + NADP+ + H2O | the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview | ? | |
cholesterol + NADPH + O2 | the enzyme is important in cholesterol metabolism in the brain, overview | Homo sapiens | (24S)-hydroxycholesterol + NADP+ + H2O | the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview | ? | |
cholesterol + NADPH + O2 | the enzyme is important in cholesterol metabolism in the brain, overview | Sus scrofa | (24S)-hydroxycholesterol + NADP+ + H2O | the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview | ? |
Synonyms | Comment | Organism |
---|---|---|
CYP46A1 | - |
Mus musculus |
CYP46A1 | - |
Homo sapiens |
CYP46A1 | - |
Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Sus scrofa |