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Literature summary for 1.14.14.24 extracted from

  • Foresta, C.; Strapazzon, G.; De Toni, L.; Perilli, L.; Di Mambro, A.; Muciaccia, B.; Sartori, L.; Selice, R.
    Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis (2011), J. Clin. Endocrinol. Metab., 96, E646-E652.
    View publication on PubMed

Application

Application Comment Organism
medicine testis samples from patients with hypospermatogenesis and Sertoli-cell-only syndrome show a lower gene and protein expression of isoform CYP2R1 and a colocalization with INSL-3, a Leydig cell marker. In all testiculopathic patients 25-hydroxyvitamin D levels are significantly lower and parathyroid hormone levels higher compared to controls. Testiculopathic patients show osteopenia and osteoporosis despite normal testosterone levels compared with controls both with increased bone-marker levels and altered dual-energy X-ray absorptiometry in the femoral neck and lumbar spine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6VVX0
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Source Tissue

Source Tissue Comment Organism Textmining
testis
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Homo sapiens
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Synonyms

Synonyms Comment Organism
CYP2R1
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Homo sapiens