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Literature summary for 1.14.14.24 extracted from

  • Cheng, J.B.; Motola, D.L.; Mangelsdorf, D.J.; Russell, D.W.
    De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase (2003), J. Biol. Chem., 278, 38084-38093.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK 293 cell Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q6VVW9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver CYP2R1 mRNA is abundant in the liver and testis Mus musculus
-
testis CYP2R1 mRNA is abundant in the liver and testis Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vitamin D3 + O2 + NADPH + H+
-
 Mus musculus 25-hydroxyvitamin D3 + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP2R1
-
 Mus musculus
cytochrome P450 2R1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function expression of CYP2R1 in HEK 293 cells leads to the transcriptional activation of the vitamin D receptor when either vitamin D2 or D3 is added to the medium. Co-expression of CYP2R1 with vitamin D 1-hydroxylase CYP27B1 elicits additive activation of vitamin D3, whereas co-expression with vitamin D 24-hydroxylase CYP24A1 causes inactivation Mus musculus