Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene CYP7A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7 alpha-hydroxylase | - |
Homo sapiens |
CYP7A1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | activation of an AMP-activated protein kinase decreases CYP7A1 mRNA, hepatocyte nuclear factor 4alpha protein, and binding to CYP7A1 chromatin | down |
Homo sapiens | high glucose stimulates bile acid synthesis and induces mRNA expression of cholesterol 7alpha-hydroxylase, the key regulatory gene in bile acid synthesis. Glucose increased ATP levels to inhibit AMPK and induce HNF4alpha to stimulate CYP7A1 gene transcription. Knockdown of ATP-citrate lyase, which converts citrate to acetyl-CoA, decreases histone acetylation, and attenuates glucose induction of CYP7A1 mRNA expression | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the phosphorylation status of CYP7A1 chromatin is important in CYP7A1 regulation, overview | Homo sapiens |
additional information | high glucose stimulates bile acid synthesis and induces mRNA expression of cholesterol 7 alpha-hydroxylase, the key regulatory gene in bile acid synthesis. Glucose decreases H3K9 methylation in CYP7A1 chromatin. Knockdown of ATP-citrate lyase, which converts citrate to acetyl-CoA, decreases histone acetylation, and attenuates glucose induction of CYP7A1 mRNA expression | Homo sapiens |