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Literature summary for 1.14.14.23 extracted from

  • Hubacek, J.A.; Bobkova, D.
    Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering (2006), Mol. Diagn. Ther., 10, 93-100.
    View publication on PubMed
Search for more literature for 1.14.14.23

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme expression is induced by cholesterol, bile acids, cytokines, steroid hormones, and thyroid hormone Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP7A1, genetic structure, the gene contains six exons and five introns and is located on chromosome 8 at 8q11-q12, CYP7A1 mRNA levels are regulated through the farnesoid X receptor and the liver X receptor by many stimuli including cholesterol, bile acids, cytokines, steroid hormones, and thyroid hormone Homo sapiens

Protein Variants

Protein Variants Comment Organism
A204C nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene, the genetic variant shows less total cholesterol level decrease in response to dietary changes in different types of dietary intervention studies compared to C204 homozygotes, overview Homo sapiens
A278C nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene Homo sapiens
C554T nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene Homo sapiens
additional information genotyping and frequency of polymorphisms in human populations, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens CYP7A1 is a rate-limiting enzyme in bile acid synthesis and therefore plays an important role in maintaining cholesterol homeostasis, cholesterol metabolism, overview 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P22680 gene CYP7A1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 CYP7A1 is a rate-limiting enzyme in bile acid synthesis and therefore plays an important role in maintaining cholesterol homeostasis, cholesterol metabolism, overview Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
-
 Homo sapiens
CYP7A1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens