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Literature summary for 1.14.14.23 extracted from

  • Abrahamsson, A.; Krapivner, S.; Gustafsson, U.; Muhrbeck, O.; Eggertsen, G.; Johansson, I.; Persson, I.; Angelin, B.; Ingelman-Sundberg, M.; Bjoerkhem, I.; Einarsson, C.; vant Hooft, F.M.
    Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration (2005), Atherosclerosis, 182, 37-45.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP7AI, genotyping, overexpression of genetic variants in Hep-G2 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information naturally occuring polymorphisms of gene CYP7AI are C203A and T469C in the promoter region, and IVS6 + G363A in the 3'-end of the gene, the genetic variants are of no physiologic importance Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens first and rate-limiting step in the neutral pathway of cholesterol metabolism 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
additional information Homo sapiens the cholesterol 7alpha-hydroxylase is critical in bile acid and cholesterol metabolism, polymorphisms of CP7A1 are of no physiologic significance, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
gene CYP7AI
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 first and rate-limiting step in the neutral pathway of cholesterol metabolism Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
additional information the cholesterol 7alpha-hydroxylase is critical in bile acid and cholesterol metabolism, polymorphisms of CP7A1 are of no physiologic significance, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
-
Homo sapiens
CYP7A1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens