Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | the enzyme is involved in bile acid biosynthesis in liver | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | enzyme activity during liver regeneration after hepatectomy, 7alpha-hydroxylase activities recover after day 3 and are not reduced on days 3, 5, or 7 compared to those of sham-operated rats | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme activity during liver regeneration after hepatectomy, 7alpha-hydroxylase activities recover after day 3 and are not reduced on days 3, 5, or 7 compared to those of sham-operated rats | Rattus norvegicus |
0.000022 | - |
day 1 after hepatectomy | Rattus norvegicus |
0.000048 | - |
day 1 after sham operation | Rattus norvegicus |
0.000058 | - |
day 3 after sham operation | Rattus norvegicus |
0.000065 | - |
day 3 after hepatectomy | Rattus norvegicus |
0.000069 | - |
day 7 after hepatectomy | Rattus norvegicus |
0.000075 | - |
day 7 after sham operation | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in bile acid biosynthesis in liver | Rattus norvegicus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
7alpha-hydroxylase | - |
Rattus norvegicus |
cholesterol 7alpha-hydroxylase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |