Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli JM109 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
abiraterone | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05093 | - |
- |
Purification (Comment) | Organism |
---|---|
metal affinity and ion exchange chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP17A1 | - |
Homo sapiens |
cytochrome P450 17A1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the bifunctional enzyme is responsible for pregnenolone C17 hydroxylation, followed by a 17,20-lyase reaction to produce dehydroepiandrosterone, the key intermediate in human synthesis of androgen and estrogen sex steroids | Homo sapiens |