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Literature summary for 1.14.14.19 extracted from
- At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17 (2011), Biochim. Biophys. Acta, 1814, 200-209.
Organism
| Organism | UniProt | Comment | Textmining |
|---|
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries. At least three factors, NF1, SF1 and SF3, control the expression level of human CYP17A1 in adrenals. Regions of the CYP17A1 gene responsible for binding transcriptional factors are: nt -107 to -85 and nt -178 to -152 for NF1-1C, nt -227 to -184 for SF1 and SF3 | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Cavia porcellus |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Mus musculus |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Rattus norvegicus |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Sus scrofa |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Bos taurus |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Ovis aries |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Felis catus |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Capra hircus |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Equus caballus |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Bison bison |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Papio sp. |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Pan troglodytes |
| evolution | the CYP17 enzymes from various species have 46-98% sequence homology, depending on the evolutionary distance between the organisms. Enzymes from different mammalian species show relatively high homology of amino acid sequences, but have different types of activity and different requirements for cytochrome b5 | Homo sapiens |
| malfunction | mutations resulting in only the 17,20-lyase deficiency are located either in the putative substrate-binding region of CYP17A1 or in the region responsible for interaction with cytochrome b5 | Homo sapiens |
| metabolism | CYP17 catalyzes the 17alpha-hydroxylation reaction of delta4-C21 steroids (progesterone derivatives) and delta5-C21 steroids (pregnenolone derivatives) aswell as the 17,20-lyase reaction producing C19-steroids, a key branch point in steroid hormone biosynthesis. Depending on CYP17 activity, the steroid hormone biosynthesis pathway is directed to either the formation of mineralocorticoids and glucocorticoids or sex hormones | Homo sapiens |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Cavia porcellus |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Mus musculus |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Rattus norvegicus |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Sus scrofa |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Bos taurus |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Ovis aries |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Felis catus |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Capra hircus |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Equus caballus |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Bison bison |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Papio sp. |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Pan troglodytes |
| metabolism | CYP17-dependent alternative steroids biosynthesis, overview | Homo sapiens |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Cavia porcellus |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Mus musculus |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Rattus norvegicus |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Sus scrofa |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Bos taurus |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Ovis aries |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Felis catus |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Capra hircus |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Equus caballus |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Bison bison |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Papio sp. |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Pan troglodytes |
| additional information | the following factors contribute to the regulation of CYP17 activities: 1. the ratio of NADPH-cytochrome P450 reductase to CYP17, i.e. the rate of delivery of reducing equivalents to the P450, 2. the presence of cytochrome b5 either as an allosteric effector or as an electron donor, 3. phosphorylation of the CYP17 protein, which affects its stability and activity, and 4. retention of the intermediate, 17-OHP5 or 17-OHP4, in the active site of CYP17, which facilitates the 17,20-lyase reaction. Expression level of CYP17A1 in adrenals is regulated by ACTH and by gonadotropic hormone in the testis and ovaries | Homo sapiens |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Cavia porcellus |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Mus musculus |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Rattus norvegicus |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Sus scrofa |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Bos taurus |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Ovis aries |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Felis catus |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Capra hircus |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Equus caballus |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Bison bison |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Papio sp. |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Pan troglodytes |
| physiological function | CYP17A1 catalyzes the 17alpha-hydroxylase and 17,20-lyase reactions using various C21-steroids as substrates, overview | Homo sapiens |
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