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Literature summary for 1.14.14.19 extracted from
- Immunohistochemical detection and biological activities of CYP17 (P450c17) in the indifferent gonad of the frog Rana rugosa (2008), J. Steroid Biochem. Mol. Biol., 112, 5-12.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| CYP17, real-time RT-PCR expression analysis | Glandirana rugosa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ketoconazole | - |
Glandirana rugosa |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| progesterone + 2 AH2 + 2 O2 | Glandirana rugosa | via 17alpha-hydroxyprogesterone | androstenedione + acetate + 2 A + 2 H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Glandirana rugosa | A6P663 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Glandirana rugosa | - |
| embryo | - |
Glandirana rugosa | - |
| gonad | n somatic cells of the indifferent gonad of males and in the interstitial cell of the testis. CYP17 expression is higher in the indifferent gonad during sex differentiation in male than in female tadpoles of Rana rugosa, overview | Glandirana rugosa | - |
| additional information | immunohistochemic analysis of enzyme localization, overview | Glandirana rugosa | - |
| tadpole | - |
Glandirana rugosa | - |
| testis | intestitial cells | Glandirana rugosa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| progesterone + 2 AH2 + 2 O2 | via 17alpha-hydroxyprogesterone | Glandirana rugosa | androstenedione + acetate + 2 A + 2 H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP17 | - |
Glandirana rugosa |
| cytochromeP450 17alpha-hydroxylase/C17-20 lyase | - |
Glandirana rugosa |
| P450c17 | - |
Glandirana rugosa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Glandirana rugosa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Glandirana rugosa |
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Release 2023.1 (January 2023)
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