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Literature summary for 1.14.14.19 extracted from

  • Patel, C.H.; Dhanani, S.; Owen, C.P.; Ahmed, S.
    Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)) (2006), Bioorg. Med. Chem. Lett., 16, 4752-4756.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1-(4-bromobenzyl)-1H-imidazole 50% inhibition of hydroxylase activity at 0.0165 mM, of 17,20-lyase activity at 0.0028 mM Rattus norvegicus
1-(4-chlorobenzyl)-1H-imidazole 50% inhibition of hydroxylase activity at 0.0298 mM, of 17,20-lyase activity at 0.0049 mM Rattus norvegicus
1-[3-(4-bromophenyl)propyl]-1H-imidazole 50% inhibition of hydroxylase activity at 0.00295 mM, of 17,20-lyase activity at 0.00033 mM Rattus norvegicus
1-[3-(4-chlorophenyl)propyl]-1H-imidazole 50% inhibition of hydroxylase activity at 0.0058 mM, of 17,20-lyase activity at 0.00055 mM Rattus norvegicus
1-[3-(4-fluorophenyl)propyl]-1H-imidazole 50% inhibition of hydroxylase activity at 0.02781 mM, of 17,20-lyase activity at 0.00196 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Rattus norvegicus
-