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Literature summary for 1.14.14.19 extracted from

  • Gilep, A.A.; Estabrook, R.W.; Usanov, S.A.
    Chimerogenesis in estimation of specificity and pathway directions for cytochrome P45017alpha catalyzed reactions (2004), Biochemistry (Moscow), 69, 364-375.
    View publication on PubMed
Search for more literature for 1.14.14.19

Protein Variants

Protein Variants Comment Organism
additional information chimeric constructions of enzyme from Bos taurus and from Cavia porcellus, structural element responsible for switching activity between DELTA4- or DELTA5-pathway is located in the region of polypeptide chain coded by exons II-V of CYP17 gene Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus Q64410
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme effectively catalyzes hydroxylation reaction for both progesterone and pregnenolone, with 17alpha-hydroxyprogesterone, also 17,20-lyase activity is realized Cavia porcellus ?
-
 ?
pregnenolone + AH2 + O2
-
 Cavia porcellus 17alpha-hydroxypregnenolone + A + H2O
-
 ?
progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Cavia porcellus 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?