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Literature summary for 1.14.14.19 extracted from

  • Njar, V.C.; Klus, G.T.; Johnson, H.H.; Brodie, A.M.
    Synthesis of novel 21-trifluoropregnane steroids: inhibitors of 17alpha-hydroxylase/17,20-lyase (17alpha-lyase) (1997), Steroids, 62, 468-473.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
20xi-hydroxy-21-trifluoropregn-4-en-3-one at 0.0006 mM 50% inhibition Rattus norvegicus
21-trifluoropregn-4-en-3,20-dione at 0.0021 mM 50% inhibition Rattus norvegicus
21-trifluoropregn-5-en-3beta,20xi-diol at 0.0044 mM 50% inhibition Rattus norvegicus
ketoconazole at 0.0019 mM 50% inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + AH2 + O2 Rattus norvegicus
-
17alpha-hydroxypregnenolone + A + H2O product eliminates at C20,21 acetate to yield dehydroepiandrosterone ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pregnenolone + AH2 + O2
-
Rattus norvegicus 17alpha-hydroxypregnenolone + A + H2O product eliminates at C20,21 acetate to yield dehydroepiandrosterone ?