Application | Comment | Organism |
---|---|---|
medicine | Hmox1 protects against amyloid beta toxicity via production of CO. Protection does not arise from inhibition of apoptosis-associated K+ efflux, but rather by inhibition of AMP-dependent protein kinase activation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in SH-SY5Y cells | Homo sapiens |
expression in SH-SY5Y cells | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | isoform Hmox1 | - |
Rattus norvegicus | P06762 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Hmox1 | - |
Homo sapiens |
Hmox1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | pharmacological induction of Hmox1 significantly ameliorates the effects of amyloid-beta1-42 in rat primary hippocampal neurons | Rattus norvegicus |
physiological function | pharmacological induction or genetic overexpression of Hmox1 significantly ameliorates the effects of amyloid-beta1-42 in SH-SY5Y cells | Homo sapiens |