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Literature summary for 1.14.14.18 extracted from

  • Wang, S.; Hannafon, B.N.; Wolf, R.F.; Zhou, J.; Avery, J.E.; Wu, J.; Lind, S.E.; Ding, W.Q.
    Characterization of docosahexaenoic acid (DHA)-induced heme oxygenase-1 (HO-1) expression in human cancer cells: the importance of enhanced BTB and CNC homology 1 (Bach1) degradation (2014), J. Nutr. Biochem., 25, 515-525.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoheme + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
biliverdin + Fe2+ + CO + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoheme + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens biliverdin + Fe2+ + CO + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Homo sapiens
HO-1 isoform Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 21 h treatment with 0.05-0.2 mM docosahexaenoic acid enhances isoform HO-1 expression through transcriptional regulation in human cancer cells. Docosahexaenoic acid induces Bach1 protein degradation, thereby enhancing the transcriptional factor Nrf2-mediated isoform HO-1 gene transcription up