Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.18 extracted from

  • Piantadosi, C.A.; Withers, C.M.; Bartz, R.R.; Macgarvey, N.C.; Fu, P.; Sweeney, T.E.; Welty-Wolf, K.E.; Suliman, H.B.
    Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression (2011), J. Biol. Chem., 286, 16374-16385.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57/BL6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Mus musculus
Hmox1
-
Mus musculus
HO-1
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus HO-1 is induced by inflammation associated both with an anti-inflammatory response and with mitochondrial biogenesis up

General Information

General Information Comment Organism
additional information in cells, Hmox1 or Nfe2l2 RNA silencing prevents IL-10 and IL-1Ra up-regulation, and HO-1 induction fails post-LPS in Nfe2l2-silenced cells and post-sepsis in Nfe2l2-/- mice Mus musculus
physiological function HO-1 together with dichloromethane induces interleukin-10 expression in liver. HO-1, acting through the Nfe2l2, i.e. Nrf2, transcription factor, links anti-inflammatory cytokine expression to activation of mitochondrial biogenesis. HO1 induction after LPS stimulates anti-inflammatory interleukin-10 and interleukin-1 receptor antagonist expression in mouse liver, human HepG2 cells, and mouse J774.1 macrophages but blunted tumor necrosis factor-alpha expression Mus musculus