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Literature summary for 1.14.14.18 extracted from
- Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants (2009), Mol. Biol. Cell, 20, 1280-1288.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| heme oxygenase-1 | - |
Homo sapiens |
| HO-1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | apoptotic cell supernatants provoke a biphasic up-regulation of HO-1. Although the first phase of HO-1 induction at 6 h is accomplished by apoptotic cell-derived sphingosine-1-phosphate acting via sphingosine-1-phosphate receptor 1, the second wave of HO-1 induction at 24 h is attributed to autocrine signaling of vascular endothelial growth factor A, whose expression and release are facilitated by sphingosine-1-phosphate | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | HO-1 is critically involved in macrophage polarization toward an M2 phenotype. HO-1 affects anti-inflammatory and antiapoptotic pathways in macrophages | Homo sapiens |
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