Cloned (Comment) | Organism |
---|---|
265-residue constructs of wild-type and mutant D140A | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D140A | exhibits resolved and relaxed 2,4-dimethyldeuterohemin resonances at low pH and at high pH | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
10.3 | - |
sequential Ni-Ni+1 connections for Ile57-Ala60, His84-Lys86, Leu93-Trp96, and Leu164-Phe167 can be observed even at pH 10.3, with chemical shift similar to those for heme oxygenase-2,4-dimethyldeuterohemin-H2O | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | high-spin heme oxygenase-2,4-dimethyldeuterohemin-H2O complex dominates at low pH, low-spin heme oxygenase-2,4-dimethyldeuterohemin-OH complex dominates at alkaline pH | Homo sapiens |