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Literature summary for 1.14.14.18 extracted from
- Interaction of heme oxygenase-2 with nitric oxide donors: is the oxygenase an intracellular sink for NO? (1999), Eur. J. Biochem., 264, 854-861.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of wild-type heme oxygenase-1 and 2 and heme oxygenase-2 C264A/C281A double mutant in Escherichia coli | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-morpholinosydnonimine | NO-donor, 27% inhibition of recombinant heme oxygenase-2 | Rattus norvegicus |  |
| S-nitroso-N-acetyl-pennicillamine | NO-donor, 23% inhibition of recombinant heme oxygenase-2 | Rattus norvegicus | |
| sodium nitroprusside | NO-donor, 58% inhibition of recombinant heme oxygenase-2 | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | hemoprotein, heme is both substrate and cofactor, heme oxygenase-2 binds heme at heme regulatory motifs with a conserved Cys-Pro pair | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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