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Literature summary for 1.14.14.17 extracted from

  • Favre, B.; Ryder, N.S.
    Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents (1996), Antimicrob. Agents Chemother., 40, 443-447.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.17

Activating Compound

Activating Compound Comment Organism Structure
Mega-9 0.3%, 44% activation Trichophyton rubrum
octyl beta-D-glucopyranoside 0.3%, 42% activation Trichophyton rubrum

Inhibitors

Inhibitors Comment Organism Structure
amorolfine 0.03 mM, 50% inhibition Trichophyton rubrum
Mega-8 0.3%, 19% inhibition Trichophyton rubrum
additional information strong inhibition by allylamines Trichophyton rubrum
SDZ 87-469 0.000020 mM, 50% inhibition Trichophyton rubrum
terbinafine 0.0000158 mM, 50% inhibition, non-competitive vs. squalene Trichophyton rubrum
tolciclate 0.000028 mM, 50% inhibition Trichophyton rubrum
tolnaftate 0.0000515 mM, 50% inhibition Trichophyton rubrum
Triton X-100 0.3%, 71% inhibition Trichophyton rubrum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0133
-
 squalene
-
 Trichophyton rubrum

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Trichophyton rubrum
-
-

Organism

Organism UniProt Comment Textmining
Trichophyton rubrum
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000012
-
 activity in microsomes Trichophyton rubrum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
squalene + NAD(P)H + O2 NADPH is slightly preferred Trichophyton rubrum (S)-squalene-2,3-epoxide + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
additional information FAD stimulates activity but is not essential Trichophyton rubrum