Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | i.e. compound SF 86-327, non-competitive inhibition | Candida albicans | |
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | i.e. compound SF 86-327, non-competitive inhibition | Candida parapsilosis | |
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | i.e. compound SF 86-327, non-competitive inhibition | Rattus norvegicus | |
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | i.e. naftifine, non-competitive inhibition | Candida albicans | |
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | i.e. naftifine, non-competitive inhibition | Candida parapsilosis | |
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | i.e. naftifine, non-competitive inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.011 | - |
squalene | - |
Rattus norvegicus | |
0.016 | - |
squalene | - |
Candida parapsilosis | |
0.05 | - |
squalene | - |
Candida albicans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Candida parapsilosis | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
squalene + NAD(P)H + O2 | NADPH is preferred | Rattus norvegicus | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? | |
squalene + NAD(P)H + O2 | NADH is preferred | Candida albicans | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? | |
squalene + NAD(P)H + O2 | NADH is preferred | Candida parapsilosis | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | required for activity | Rattus norvegicus | |
FAD | required for activity | Candida albicans | |
FAD | required for activity | Candida parapsilosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00003 | - |
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | - |
Candida albicans | |
0.00004 | - |
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | - |
Candida parapsilosis | |
0.00034 | - |
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | - |
Candida parapsilosis | |
0.0011 | - |
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | - |
Candida albicans | |
0.077 | - |
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | - |
Rattus norvegicus | |
1.44 | - |
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | - |
Rattus norvegicus |