Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.16 extracted from

  • Miguel, R.N.; Chen, S.; Nikfarjam, L.; Kominami, S.; Carpenter, B.; Dal Pra, C.; Betterle, C.; Zanchetta, R.; Nakamatsu, T.; Powell, M.; Hewer, R.; Blundell, T.L.; Smith, B.R.; Furmaniak, J.
    Analysis of the interaction between human steroid 21-hydroxylase and various monoclonal antibodies using comparative structural modelling (2005), Eur. J. Endocrinol., 153, 949-961.
    View publication on PubMed

Application

Application Comment Organism
medicine study on the effects of enzyme-specific monoclonal antibodies on enzyme activity by comparative structural modelling. Antibodies with epitopes located distant from the enzyme active sites have no effect on activity. An antibody with epitope close to the redox binding protein binding site results in almost 50% decrease in activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-