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Literature summary for 1.14.14.14 extracted from
- Differential sensitivity to in vitro inhibition of cytochrome P450 aromatase (CYP19) activity among 18 freshwater fishes (2019), Toxicol. Sci., 170, 394-403 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| imazalil | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Catostomus commersonii |  |
| imazalil | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Esox lucius | |
| imazalil | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Oncorhynchus mykiss | |
| imazalil | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Pimephales promelas | |
| imazalil | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Polyodon spathula | |
| letrozole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Catostomus commersonii | |
| letrozole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Esox lucius | |
| letrozole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Oncorhynchus mykiss | |
| letrozole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Pimephales promelas | |
| letrozole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Polyodon spathula | |
| Prochloraz | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Catostomus commersonii | |
| Prochloraz | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Esox lucius | |
| Prochloraz | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Oncorhynchus mykiss | |
| Prochloraz | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Pimephales promelas | |
| Prochloraz | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Polyodon spathula | |
| Propiconazole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Catostomus commersonii | |
| Propiconazole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Esox lucius | |
| Propiconazole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Oncorhynchus mykiss | |
| Propiconazole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Pimephales promelas | |
| Propiconazole | inhibition of aromatase activity in Polyodon spathula, Esox lucius, Catostomus commersonii, Oncorhynchus mykiss, and Pimephales promelas. The rank order of potency for these fishes based on IC50 is fadrozole > letrozole > imazalil > prochloraz = propiconazole. On average, fadrozole is 5-, 10-, 250-, and 50fold more potent than letrozole, imazalil, prochloraz, and propiconazole, respectively | Polyodon spathula | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Catostomus commersonii | - |
- |
- |
| Esox lucius | - |
- |
- |
| Oncorhynchus mykiss | - |
- |
- |
| Pimephales promelas | - |
- |
- |
| Polyodon spathula | - |
- |
- |
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