Literature summary for 1.14.14.14 extracted from

Williams, G.P.; Darbre, P.D.
Low-dose environmental endocrine disruptors, increase aromatase activity, estradiol biosynthesis and cell proliferation in human breast cells (2019), Mol. Cell. Endocrinol., 486, 55-64 .

Search for more literature for 1.14.14.14

Application

Application	Comment	Organism
medicine	phenolic endocrine-disrupting compounds DDT, methoxychlor, benzophenone-2, bisphenol A, bisphenol S, 4-phenylphenol and n-butylparaben upregulate aromatase mRNA expression, increase aromatase activity, significantly increase the aromatase-induced biosynthesis of 17beta-estradiol, and increase ERalpha positive breast cell proliferation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
letrozole	0.001 mM, complete inhibition of activity in cell lines	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11511	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HMF3A cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
ZR-75-1 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CYP19A1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	expression is upregulated upon treatment with benzophenone-2, 4-phenylphenol, bisphenol A, bisphenol S, and n-butylparaben. Cells treated with DDT, methoxychlor, benzophenone-2,4-phenylphenol, bisphenol A, bisphenol S, and n-butylparaben, display significantly increased aromatase enzyme activity	up

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Release 2023.1 (January 2023)