Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6alpha-allylandrost-4-ene-3,17-dione | - |
Homo sapiens | |
6alpha-allylandrosta-1,4-diene-3,17-dione | competitive, irreversible, at 0.010 mM 99.2% inhibition of activity in MCF-7aro cells | Homo sapiens | |
6alpha-methylandrost-4-en-17-one | - |
Homo sapiens | |
6alpha-methylandrost-4-ene-3,17-dione | competitive, reversible, at 0.010 mM 98.5% inhibition of activity in MCF-7aro cells | Homo sapiens | |
7alpha-allyl-4-hydroxyandrost-4-ene-3,17-dione | - |
Homo sapiens | |
exemestane | - |
Homo sapiens | |
formestane | - |
Homo sapiens | |
additional information | for modification of androstane inhibotrs, position C-6alpha is better to functionalize than C-7alpha, except when there is a C-4 substituent simultaneously | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11511 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins | - |
Homo sapiens | estrone + formate + 4 H2O + 3 oxidized flavoproteins | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000023 | - |
6alpha-allylandrosta-1,4-diene-3,17-dione | pH 7.4, 37°C | Homo sapiens | |
0.000025 | - |
6alpha-methylandrost-4-ene-3,17-dione | pH 7.4, 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000042 | - |
pH 7.4, 37°C | Homo sapiens | formestane | |
0.00005 | - |
pH 7.4, 37°C | Homo sapiens | exemestane | |
0.000055 | - |
pH 7.4, 37°C | Homo sapiens | 6alpha-allylandrosta-1,4-diene-3,17-dione | |
0.00006 | - |
pH 7.4, 37°C | Homo sapiens | 6alpha-methylandrost-4-ene-3,17-dione | |
0.000105 | - |
pH 7.4, 37°C | Homo sapiens | 6alpha-allylandrost-4-ene-3,17-dione | |
0.00011 | - |
pH 7.4, 37°C | Homo sapiens | 7alpha-allyl-4-hydroxyandrost-4-ene-3,17-dione | |
0.00017 | - |
pH 7.4, 37°C | Homo sapiens | 6alpha-methylandrost-4-en-17-one |