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Literature summary for 1.14.14.14 extracted from
- Let-7g inhibits synthesis of estradiol by downregulating activity of aromatase in JEG3 cells (2019), J. Cell. Biochem., 120, 1819-1826 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in the trophoblast choriocarcinoma cell line, JEG-3, the expression of let-7g microRNA is downregulated, but upregulated in primary term trophoblast. Aromatase is upregulated in JEG-3 cells but downregulated in primary trophoblast. Let-7g antagomirs and mimics increase and decrease aromatase expression, respectively, and Let-7g directly targets the 3'-untranslated region of CYP19A1 mRNAlet-7g antagomirs and mimics robustly increase and decrease production of estradiol, respectively | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P11511 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| JEG-3 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP19A1 | - |
Homo sapiens |
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