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Literature summary for 1.14.14.137 extracted from

  • Todoroki, Y.; Naiki, K.; Aoyama, H.; Shirakura, M.; Ueno, K.; Mizutani, M.; Hirai, N.
    Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole (2010), Bioorg. Med. Chem. Lett., 20, 5506-5509.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
CYP707A3, coexpression with Arabidopsis thaliana P450 reductase ATR2 in Escherichia coli Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
(1E)-1-(4-chlorophenyl)-2-[2-(hydroxymethyl)-1H-imidazol-1-yl]-4,4-dimethylpent-1-en-3-ol 31% inhibition at 0.01 mM Arabidopsis thaliana
(1E)-1-(4-chlorophenyl)-2-[5-(hydroxymethyl)-1H-imidazol-1-yl]-4,4-dimethylpent-1-en-3-ol 95% inhibition at 0.01 mM Arabidopsis thaliana
1-[(1E)-1-(4-chlorophenyl)-3-ethoxy-4,4-dimethylpent-1-en-2-yl]-5-(ethoxymethyl)-1H-imidazole 62% inhibition at 0.01 mM Arabidopsis thaliana
1-[(1E)-1-(4-chlorophenyl)-3-hydroxy-4,4-dimethylpent-1-en-2-yl]-1H-imidazole-5-carbaldehyde 91% inhibition at 0.01 mM Arabidopsis thaliana
1-[(1E)-1-(4-chlorophenyl)-3-methoxy-4,4-dimethylpent-1-en-2-yl]-5-(methoxymethyl)-1H-imidazole 95% inhibition at 0.01 mM Arabidopsis thaliana
methyl (2E)-3-[1-[(1E)-1-(4-chlorophenyl)-3-hydroxy-4,4-dimethylpent-1-en-2-yl]-1H-imidazol-5-yl]prop-2-enoate 98% inhibition at 0.01 mM Arabidopsis thaliana
methyl (2Z)-3-[1-[(1E)-1-(4-chlorophenyl)-3-hydroxy-4,4-dimethylpent-1-en-2-yl]-1H-imidazol-5-yl]prop-2-enoate 100% inhibition at 0.01 mM Arabidopsis thaliana
uniconazole
-
 Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2 Arabidopsis thaliana
-
 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2
-
 Arabidopsis thaliana 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
ABA 8'-hydroxylase
-
 Arabidopsis thaliana
abscisic acid 8'-hydroxylase
-
 Arabidopsis thaliana
CYP707A
-
 Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00012
-
 methyl (2E)-3-[1-[(1E)-1-(4-chlorophenyl)-3-hydroxy-4,4-dimethylpent-1-en-2-yl]-1H-imidazol-5-yl]prop-2-enoate
-
 Arabidopsis thaliana
0.00016
-
 (1E)-1-(4-chlorophenyl)-2-[5-(hydroxymethyl)-1H-imidazol-1-yl]-4,4-dimethylpent-1-en-3-ol
-
 Arabidopsis thaliana
0.00019
-
 1-[(1E)-1-(4-chlorophenyl)-3-methoxy-4,4-dimethylpent-1-en-2-yl]-5-(methoxymethyl)-1H-imidazole
-
 Arabidopsis thaliana
0.00022
-
 methyl (2Z)-3-[1-[(1E)-1-(4-chlorophenyl)-3-hydroxy-4,4-dimethylpent-1-en-2-yl]-1H-imidazol-5-yl]prop-2-enoate
-
 Arabidopsis thaliana
0.00024
-
 1-[(1E)-1-(4-chlorophenyl)-3-hydroxy-4,4-dimethylpent-1-en-2-yl]-1H-imidazole-5-carbaldehyde
-
 Arabidopsis thaliana