Literature summary for 1.14.14.1 extracted from

Diczfalusy, U.; Miura, J.; Roh, H.K.; Mirghani, R.A.; Sayi, J.; Larsson, H.; Bodin, K.G.; Allqvist, A.; Jande, M.; Kim, J.W.; Aklillu, E.; Gustafsson, L.L.; Bertilsson, L.
4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians (2008), Pharmacogenet. Genomics, 18, 201-208.

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Application

Application	Comment	Organism
medicine	plasma concentration of 4beta-hydroxycholesterol may be used as an endogenous marker of CYP3A activity. Concentration of 4beta-hydroxycholesterol increases with the number of active CYP3A5 alleles in Koreans, Swedes and Tanzanians	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P20815	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
quinine + [reduced NADPH-hemoprotein reductase] + O2	-	Homo sapiens	3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP3A5	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	differences in the activity of both CYP3A4 and CYP3A5 in Koreans, Swedes and Tanzanians. Both 4beta-hydroxycholesterol and quinine/3-hydroxyquinine metabolic ratio show a higher CYP3A activity in women than in men	Homo sapiens

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Release 2023.1 (January 2023)