Any feedback?
Literature summary for 1.14.13.9 extracted from
- The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats (2005), Clin. Chim. Acta, 360, 67-80.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kynurenine + NADPH + O2 | Rattus norvegicus | - |
3-hydroxy-kynurenine + NADP+ + H2O | - |
? |  |
| additional information | Rattus norvegicus | age affects the enzyme activities of tryptophan metabolism along the kynurenine pathway, one of the various tryptophan metabolic routes, kynurenine 3-monooxygenase activity progressively decreases with age in liver and kidney of newborn to mature rats, quantitative overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
SpragueDawley rats of ages 1 week, 23, 12 and 18 months | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | enzyme activity decreases significantly with age | Rattus norvegicus | - |
| liver | enzyme activity decreases significantly with age | Rattus norvegicus | - |
| small intestine | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000012 | - |
liver of 2-3 months-old rats | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kynurenine + NADPH + O2 | - |
Rattus norvegicus | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? | |
| additional information | age affects the enzyme activities of tryptophan metabolism along the kynurenine pathway, one of the various tryptophan metabolic routes, kynurenine 3-monooxygenase activity progressively decreases with age in liver and kidney of newborn to mature rats, quantitative overview | Rattus norvegicus | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
