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Literature summary for 1.14.13.9 extracted from
- Inhibition of L-kynurenine 3-hydroxylase from Saccharomyces carlsbergensis by alpha-keto acid derivatives of branched chain amino acids (1982), J. Nutr. Sci. Vitaminol., 28, 191-201.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxo acid derivatives | of the 3 branched chain amino acids | Saccharomyces pastorianus |  |
| 2-oxoglutarate | mixed type inhibitor | Saccharomyces pastorianus | |
| alpha-Ketoisocaproate | non competitive inhibition | Saccharomyces pastorianus | |
| pyruvate | mixed type inhibitor | Saccharomyces pastorianus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial outer membrane | - |
Saccharomyces pastorianus | 5741 | - |
| mitochondrion | - |
Saccharomyces pastorianus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces pastorianus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Saccharomyces pastorianus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-kynurenine + NADPH + O2 | - |
Saccharomyces pastorianus | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Saccharomyces pastorianus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4.2 | - |
alpha-Ketoisocaproate | inhibition for L-kynurenine | Saccharomyces pastorianus | |
| 8.3 | - |
alpha-Ketoisocaproate | inhibition for NADPH | Saccharomyces pastorianus | |
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