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Literature summary for 1.14.13.9 extracted from

  • Saito, K.; Quearry, B.J.; Saito, M.; Nowak, T.S.Jr.; Markey S.P.; Heyes, M.P.
    Kynurenine 3-hydroxylase in brain: species activity differences and effect of gerbil cerebral ischemia (1993), Arch. Biochem. Biophys., 307, 104-109.
    View publication on PubMed
Search for more literature for 1.14.13.9

Inhibitors

Inhibitors Comment Organism Structure
anthranilic acid 22% inhibition at 2 mM and 11% inhibition at 0.2 mM Meriones unguiculatus
EDTA 68% inhibition at 2 mM Meriones unguiculatus
Kynurenic acid 13% inhibition at 2 mM and 5% inhibition at 0.2 mM Meriones unguiculatus
L-tryptophan 35% inhibition at 2 mM and 22% inhibition at 0.2 mM Meriones unguiculatus
xanthurenic acid 48% inhibition at 2 mM and 13% inhibition at 0.2 mM Meriones unguiculatus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0164
-
 L-kynurenine
-
 Meriones unguiculatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-kynurenine + NADPH + O2 Rattus norvegicus
-
 ? + NADP+
-
 ?
L-kynurenine + NADPH + O2 Meriones unguiculatus increased activity in injured brain regions following cerebral ischemia ? + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Macaca mulatta
-
 male rhesus macaques
-
Meriones unguiculatus
-
 female mongolian gerbil
-
Mus musculus
-
 mouse, strain D57Bl/6J
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
brain
-
 Meriones unguiculatus
-
brain
-
 Macaca mulatta
-
intestine
-
 Meriones unguiculatus
-
kidney
-
 Rattus norvegicus
-
kidney
-
 Meriones unguiculatus
-
liver
-
 Rattus norvegicus
-
liver
-
 Meriones unguiculatus
-
lung
-
 Meriones unguiculatus
-
spleen
-
 Meriones unguiculatus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus
additional information
-
-
 Homo sapiens
additional information
-
-
 Rattus norvegicus
additional information
-
-
 Macaca mulatta
additional information
-
 specific activity in various organs Meriones unguiculatus

Storage Stability

Storage Stability Organism
-70°C no loss of enzymatic activity after 24 hours Meriones unguiculatus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + NADPH + O2
-
 Rattus norvegicus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
L-kynurenine + NADPH + O2
-
 Meriones unguiculatus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
L-kynurenine + NADPH + O2
-
 Rattus norvegicus ? + NADP+
-
 ?
L-kynurenine + NADPH + O2 increased activity in injured brain regions following cerebral ischemia Meriones unguiculatus ? + NADP+
-
 ?

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
7 10 50% activity at 7°C and 10°C Meriones unguiculatus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4
-
 no loss of enzymatic activity after 24 hours Meriones unguiculatus
25
-
 22% loss of enzymatic activity after 24 hours Meriones unguiculatus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 8.5
-
 Meriones unguiculatus